THY1 and Alzheimer disease: Recently, it was also reported that the hemizygous transgenic McGill-R-Thy1-APP (Tg+/−) rat, the least genetically aggressive AD transgenic model developed so far, also showed impairments in auditory fear conditioning and in the Novel Object Recognition and Location (NORL) task as early as 3 months of age (Iulita et al., 2014).