GRIK1 and alcohol dependence: Recently, a single nucleotide polymorphism of GluK1 gene (GRIAK1) in the 3′ untranslated intronic region has been suggested to associate with alcohol dependence and shown to affect the anti-alcoholic treatment effects of topiramate that is a non-NMDA glutamate receptor antagonist (Kranzler et al., 2009, 2014).