In addition, human genetic linkage studies show a strong association of GABRA2 (the gene encoding the α2 subunit) with alcohol dependence (Edenberg et al., 2004; Haughey et al., 2008; Soyka et al., 2008; Roh et al., 2011; Villafuerte et al., 2012). The gene discussed is GABRA2; the disease is alcohol dependence.