IMMT and early-onset autosomal dominant Alzheimer disease: Breakdown or modification of cytoskeletal elements or motor proteins are common pathologies in neurological disorders such as Alzheimer's Disease and amyotrophic lateral sclerosis and can negatively affect neuron structure and function in terms of cellular integrity, axonal transport, and signaling (Coleman, 2005; Conforti et al., 2007; Cuchillo-Ibanez et al., 2008; Shea and Chan, 2008; Morfini et al., 2009a; Shea et al., 2009).