NR3C1 and breast cancer: Interestingly, stratifying patients of the METABRIC cohort according to disease stage indicated that low GR expression might predict poor survival only in advanced stages of disease (Fig. 7b), and similar analysis of two smaller cohort of patients42, 43 showed that low GR associates with poor prognosis only in grade 2 and grade 3 patients, but no such association was found in the grade 1 group (Supplementary Fig. 6B), raising the possibility that loss of GR occurs late in breast cancer progression.