EGFR and non-small cell lung carcinoma: Two recent studies reviewed published data regarding this topic; Lee and colleagues in their meta-analysis concluded that EGFR mutations are a predictive biomarker of PFS benefit to anti-EGFR TKIs; Goss and co-workers confirmed this conclusion, and also suggested that an activating mutation predicts a greater likelihood of antitumor response and that there are a proportion of EGFR wild-type patients with NSCLC who will still gain some benefit from this therapy [122],[123].