Since IDH1 is the most frequently mutated gene in 1p19q co-deleted ODG and CIC is mutated in ~70% of oligodendrogliomas, we studied the effects of expressing wild type and mutant CIC in combination with IDH1-R132H on cell proliferation, cell survival and cell death using ODG cell culturing conditions. The gene discussed is IDH1; the disease is oligodendroglioma.