Interestingly, this analysis identified and confirmed a few genes that we previously reported to be associated with aggressive PCa including homeobox D3 (HOXD3), T-box 15 (TBX15), and T-box-3 (TBX3), as well as genes formerly reported methylated in PCa including homeobox D8 (HOXD8) and ventral anterior homeobox 1 (VAX1). This evidence concerns the gene HOXD3 and posterior cortical atrophy.