LGALS7 and ovarian cancer: In contrast, gal-7 was not detected in ovarian cancer cells harboring a wild-type p53 (A2780 and COV434 cells) or cells with a p53null genotype (e.g., SK-OV-3) [13] Transfection of SK-OV-3 cells with expression vectors encoding p53 with mutations at codons 175, 273, and 248 all induced de novo expression of gal-7 at both the mRNA and protein level compared to cells transfected with a control (empty) vector (Fig. 2 C-D).