TRPS1 and trichorhinophalangeal syndrome: Trps1, mapped to human chromosome 8q23-24, is implicated in trichorhinophalangeal syndrome (TRPS),[6-11] also known as Langer-Giedion syndrome, a genetic disorder characterized by short stature, cone-shaped ends of the long bones (epiphyses), and distinctive facial features linked to skeletal abnormalities.