TRPS1 was found to be amplified in SK-Br-3 breast cancer cell lines[74] as well as in ZR-75-1, T-47D and MCF7 cell lines,[35] and in >90% of breast cancers.[38] In contrast, MDA-MB-231 breast cancer cells exhibit low TRPS1 mRNA and protein levels. The gene discussed is TRPS1; the disease is breast carcinoma.