TRPS1 and breast carcinoma: Several reports have provided evidence to show that TRPS1 inhibits EMT during breast cancer development.[36, 41-43] The six hallmarks of cancer—sustained proliferative signaling, evasion of growth suppressors, resistance against cell death, replicative immortality, induction of angiogenesis, and activation of invasion and metastasis[51]—endow cancer cells with a capacity for uncontrolled growth and metastasis: the two defining features of cancer.