NKG2D recognizes different MHC class I-homologous ligands (NKG2DL), including the MHC class I-chain related molecules A (MICA) and B (MICB) and the UL16-binding proteins (ULBP)1-6 [4, 5], which are also present on the surface of glioma cells [6]. Here, MICB is linked to central nervous system cancer.