ROCK1 and colorectal cancer: Further studies have shown that the inactivation of miR-148a has led to the overproduction of oncogenic ROCK1, a kinase that promotes cell migration and invasion in gastric cancer[31]; Bcl-2, an antiapoptotic protein that increases cell survival in colorectal cancer [21]; and WNT10B, a signaling protein that stimulates β-catenin activation and cancer-associated fibroblast cell motility [8].