It has been demonstrated that LMP1 up-regulates DNA methyltransferases (DNMTs) in NPC and causes the inactivation of tumor suppressor genes (TSGs) such as E-cadherin [5], RASSF1A [6 ], p16 [7] and HoxA2 [8] through hypermethylation. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.