NFKB1 and ovarian carcinoma: Importantly, TAK1 activates NF-κB signaling activity through the increased phosphorylation at Ser412, and such activated TAK1/NF-κB signaling cascade is indispensable in promoting ovarian cancer cell growth, anchorage independent growth ability, chemoresistance, as well as in vitro and in vivo metastasis in ovarian cancer.