So far, several potential therapeutic agents able to interfere with the MDM2-p53 interaction by different mechanisms, such as Nutlins, benzodiazepines, RITA (Reactivation of p53 and Induction of Tumour cell Apoptosis), spiro-oxindoles and quinolinols, have been developed [27, 28, 30, 52-56]. This evidence concerns the gene MDM2 and neoplasm.