However, several studies showed that mutated p53 found in the papillary, chromophobe, and ccRCC subtypes, appears to be accompanied by metastatic progression of the disease and poor survival of patients with RCC and a correlation of p53 expression with TNM classification seems to suggest that p53 mutations might have an important role in the progression of RCC [17-19]. The gene discussed is TP53; the disease is renal cell carcinoma.