IGFBP1 and digestive system neoplasm: Transfection studies have shown this miRNA to act as a master cell cycle regulator at the G1/S checkpoint by targeting CDK6[45] and at G2/M arrest by targeting PLK1, PTTG1, CCNB1, CDC2, CDC20 and TOP2A[46], and this miRNA also affects cell proliferation in A549 lung cells by regulating IGFBP1 and IGF2[47] and in gastrointestinal tumor cells by direct targeting KIT[48].