In the following years, the selected candidate gene studies have also identified associations of complement-related genes with AMD development and progression, including different variants of complement factor B (CFB32Q rs641153), factor C3 (C3102G rs2230199), factor CFI (rs4698775), or factors C4A or C4B, which both flank rs429608 locus [32, 38, 57–59]. Here, C3 is linked to age-related macular degeneration.