Most importantly, AMD-derived drusen also contain almost all of the complement proteins, including regulatory proteins (CFH, vitronectin, and clusterin), the products of CS activation and degradation (C1q, C3, C3a, C3b, and C5a), and members of the terminal CS pathway comprising the MAC components (i.e., 5, 6, 8 (α, β, and γ), and 9) in the separated and complex form [14, 69]. This evidence concerns the gene VTN and age-related macular degeneration.