CSF2 and posterior cortical atrophy: GVAX is a whole-cell vaccine comprised of a mixture of 2 human PCa cell lines, LNCaP (androgen-sensitive; derived from a lymph node metastasis) and PC3 (androgen-insensitive; derived from a bone metastasis), which are modified to constitutively express GM-CSF and irradiated to prevent cell replication [69].