CTLA4 and neoplasm: In a preclinical model of PCa, in vivo blockade of murine CTLA-4 with an antibody significantly delayed the growth of subcutaneous TRAMP-C1 tumours [49], derived from Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice [50, 51] which spontaneously develop PCas due to prostate-specific expression of Simian virus 40 (SV40) large T antigen (Tag).