For example, vaccination of transgenic mice expressing human carcinoembryonic antigen (CEA-Tg) with recombinant Vaccinia and Fowlpox vectors encoding for CEA and TRI-COM can facilitate rejection of CEA-expressing murine colon carcinomas, an effect dependent on CD4+ and CD8+ T cells but not NK cells [64]. Here, CEACAM5 is linked to colon carcinoma.