P2RX7 and osteoarthritis: Moreover, in two independent human chronic pain cohorts, a cohort with pain after mastectomy and a cohort with osteoarthritis, authors observed a genetic association between lower pain intensity and the hypofunctional His270 allele of P2X7 receptor, further suggesting that selectively targeting P2X7 pore formation may be a new strategy for individualizing the treatment of chronic pain [65].