AP-1 has been reported to be involved in cell apoptosis [5], and it was reported that the activation of the cfos and cjun components of the AP-1 transcription factor increases sensitivity of prostate cancer cells to the tumor necrosis factor related apoptosis inducing ligand (TRAIL) pathway of apoptosis by negative regulation and repression of the antiapoptotic molecule c-FLIP(L) [6]. The gene discussed is FOS; the disease is Familial prostate cancer.