As illustrated in the RE-LY (randomized evaluation of long-term anticoagulation therapy) study [41], 25% of the patients on anticoagulant therapy required a transitory cessation during the two years of follow-up while, in the ROCKET-AF (rivaroxaban once daily oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and embolism in atrial fibrillation) study [42], 33% of the patients experienced a temporary interruption of anticoagulant therapy. This evidence concerns the gene F10 and atrial fibrillation.