As this transcription factor coordinates the expression of genes regulated by antioxidant response elements, the Boc-2-resistant Nrf2-dependent effects of LXA4 described by Wu and collaborators [74], that is, increased expression of HO-1 (a redox-sensitive inducible enzyme) and synthesis of GSH (an antioxidant protein), constitute an important ALX/FPR2 receptor-independent mechanism to protect cells from oxidative damage following stroke. This evidence concerns the gene HMOX1 and stroke disorder.