SOD1 and Keratoconjunctivitis sicca: Several eye diseases, such as age-related macular degeneration, cataracts, dry eye, phacoemulsification, and presbyopia, are closely related to the aging process [32, 34]. Sod1 deficiency induced the development of drusen-like deposits in the retina, choroidal neovascularization, and retinal pigment epithelium dysfunction, thus resulting in age-related retinal degenerative disorders, including age-related macular degeneration [13, 14].