A number of studies have demonstrated that Lys49 PLA2 homologues induce myonecrosis by a catalytic-independent mechanism, involving amino acids at their C-terminal region which affect the integrity of the sarcolemma (Lomonte et al., 1994; Núñez, Angulo & Lomonte, 2001; Chioato et al., 2002; Chioato & Ward, 2003; Lomonte, Angulo & Calderón, 2003; dos Santos et al., 2009; Lomonte & Rangel, 2012; Fernandes et al., 2013; Fernández et al., 2013). Here, PLA2G2A is linked to gas gangrene.