Yoon et al. [40], in their study of 713 patients with surgically resected esophageal adenocarcinomas (EAC), found HER2 positivity in 17% patients and it was significantly associated with lower tumor grade, less invasiveness, fewer malignant nodes, and the presence of adjacent Barrett's esophagus (BE). The gene discussed is ERBB2; the disease is esophageal adenocarcinoma.