Moreover, hs-CRP in non-diabetic subjects was associated with decreased HDL-c and IS and increased BMI, waist circumference, SBP, DBP, TG, FBG, insulin, HOMA-IR and HOMA-β, which is in line with previous studies demonstrating a significant correlation between CRP levels and features of the MetS; including adiposity, hyperinsulinemia and IR [55, 56]. The gene discussed is INS; the disease is hyperinsulinism.