Our results show that adiponectin levels and that of leptin and LAR exhibit opposing and variable correlations with obesity, IR and the components of the metabolic syndrome; whereby leptin levels and LAR were associated with decreased IS and increased BMI, waist circumference, SBP, DBP, TG, FBG, insulin, HOMA-IR and HOMA-β. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.