The results presented in our study shows plasma adiponectin not to be affected by diabetes per se whereby adiponectin was significantly lower in obese individuals as compared to both control and non-obese Type 2 DM, with no difference in adiponectin between non-obese Type 2 DM and control group; thus suggesting that the often reported alterations in plasma adiponectins in Type 2 DM [32, 34, 35] may be due to excess adipose tissue mass/ obesity. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.