NFKB1 and colitis: However, AC-mix inhibitied the expression of iNOS and COX-2 in acute DSS-induced colitis, as well as the activation of NF-κB. AC-mix (20 mg/kg) suppressed DSS-induced TNF-α, IL-1β, and IL-6 expressions by 84.7%, 71.2%, and 73.2%, respectively.