In conclusion, based on rapid EB effects on ADD (0.25 h), its inhibition by Mk801, and inability of anisomycine (in this study) and tamoxifen to prevent AD prolongation, the acute effect of EB on kindled seizures may be induced more via a non-genomic membrane glutamate receptor rather than intracellular estrogenic receptors. The gene discussed is ESR1; the disease is Alzheimer disease.