NTRK1 and cancer: Chromosomal rearrangements involving neurotrophic tyrosine receptor kinases (NTRKs) can also occur in thyroid carcinomas and are known as TRK rearrangements. NTRK1 and NTRK3 fusions have been reported in multiple cancers including glioblastoma, lung cancer, and in 1-2% of PTC [21, 54, 55] and have a strong correlation with exposure to radiation [4, 56].