Dividing subjects according to tertiles of insulin resistance as measured by HOMA-IR (T1 < 1.53, 1.53 ≤ T2 ≤ 3.01, and T3 > 3.01) showed strong correlation between subjects with higher HOMA-IR levels and increased ghrelin level in Arab males (P-trend = 0.0202) as shown in Figure 5(a). The gene discussed is GHRL; the disease is Insulin resistance.