The observation that the expression of NOX1, NOXA1, NOXO1, and p22PHOX is increased during TNFα-induced colitis is in agreement with previous in vitro studies showing that treatment of T84 colon epithelial cells with TNFα increased NOX1 and NOXO1 expression at the mRNA and protein levels [46, 55]. The gene discussed is NOXO1; the disease is colitis.