In particular, we examined the expression of NOX1 and the effect of apocynin (4-hydroxy-3-methoxyacetophenone), an NADPH oxidase inhibitor with antioxidant properties originally extracted from the roots of the Himalayan herb Picrorhiza kurroa [28], on key features associated with the mouse model of acute colitis induced by TNFα. This evidence concerns the gene NOX1 and colitis.