P2RX7 and schistosomiasis: Here, we used a combination of ATP-induced permeabilization and intracellular Ca2+ measurement assays to show that, during the chronic phase of schistosomiasis, there is a reduction in the ATP-dependent P2X7 receptor function in macrophages (Figures 1 and 2), similar to that observed in mesenteric endothelial cells using the same experimental model [43].