To evaluate whether the reduction in P2X7 receptors function observed in schistosomiasis and in TGF-β1-treated cells was due, at least in part, to changes in P2X7 receptor expression, we quantified both P2X7 protein expression and the transcription from the P2rx7 locus by Western blotting and qRT-PCR, respectively. This evidence concerns the gene P2RX7 and schistosomiasis.