In conclusion, our study demonstrates for the first time that CaP-RR cells are associated with cell cycle arrest in G0/G1 and S phases, inactivation of apoptosis pathway proteins, activation of cell cycle checkpoint, autophagy, NHEJ and HR repair pathway proteins; that combination of the dual PI3K/mTOR inhibitors with RT can greatly repress tumor colony growth, induce more apoptosis and improve radiosensitivity. The gene discussed is MTOR; the disease is neoplasm.