RAD50 and melanoma: The same effect was described for the HDACi PCI-24781.33 In fact, it has been reported that SAHA affects the expression of proteins involved in several mechanisms of DNA repair: homologous recombination, non-homologous end joining or base excision repair19 in different kinds of tumor cells, such as RAD50 and MRE11 in prostate and lung cancer cells,10 Ku70, Ku80 and RAD50 in melanoma cells34 and Rad51 and BRCA1 in prostate cancer cells.35 HDACi-induced impairment of the DNA repairing potential could explain why antioxidant treatment does not prevent DSB formation in LN229 glioma cells.