CASP3 and melanoma: Melanoma cells from neoplastic nodules removed at the end of treatment showed enhanced positivity for terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) and cleaved caspase 3, associated with downmodulation of P-ERK and Apollon, in animals treated with the AZD6244–TRAIL association, compared with single treatments (Figure 6b).