TNFSF10 and melanoma: A pan caspase inhibitor (z-vad-fmk) completely abolished the increase in apoptosis induced by the addition of TRAIL to the AZD6244–BEZ235 combination, even in TRAIL-resistant (Me13) or in weakly susceptible (Me5) melanomas, but did not impact on cell death promoted by the AZD6244–BEZ235 combination (Figures 3c and d).