The inhibitory effects of AZD6244–TRAIL treatment on master regulators of angiogenesis, such as TGFβ1, HIF1α and Myc, as well as on production of angiogenic molecules as VEGFα, were observed at a time (8–18 h of treatment) when no significant melanoma cell death was yet induced, suggesting that the observed anti-angiogenic effect was not simply explained by increased melanoma apoptosis. The gene discussed is HIF1A; the disease is melanoma.