Among 10 fetal SNPs found to be associated with the risk of CTDs in combination with obesity, three SNPs reside in the glutathione S-transferase alpha 3 (GSTA3) gene, three SNPs are in the adenosylhomocysteinase-like 2 (AHCYL2) gene, three SNPs are in the DNA (cytosine-5-)-methyltransferase 3 alpha (DNMT3A) gene, and the other SNP resides in the GCLC gene. This evidence concerns the gene GCLC and obesity due to melanocortin 4 receptor deficiency.