However, although we have used one normal pancreatic as the calibrator for gene expression measurement and other samples in close proximity or far away from the tumor as controls, we thought that further investigations using a greater number of normal pancreatic tissues and tumor samples are needed to re-examine more precisely the HDAC and SIRTs gene expression patterns in pancreatic cancer. The gene discussed is HDAC9; the disease is familial pancreatic carcinoma.