Glanzmanns thrombasthenia (GT) is a rare (1: 200,000) congenital autosomal recessive bleeding disorder caused by either lack or dysfunction of the platelet integrin αIIbβ3, encoded by genes ITGA2B and ITGB3. The integrin serves as a receptor for fibrinogen and von Willebrand factor along with some other plasma glycoproteins. The gene discussed is VWF; the disease is Glanzmann thrombasthenia 1.