Amongst bleeding disorders, hemophilia A (FVIII deficiency), hemophilia B (FIX deficiency) and von Will brand disease (vWD) are most commonly occurring, whereas deficiencies of fibrinogen, prothrombin (FII), factor V (FV), combined factor V and VIII (FV+VIII), factor VII (FVII), factor X (FX), factor XI (FXI) and factor XIII (FXIII), along with platelet disorders, Glanzmanns Thrombasthenia (GT) and Bernard Soulier Syndrome (BSS) are rare worldwide, including India. The gene discussed is F5; the disease is von Willebrand disease (hereditary or acquired).