GATA3, one of our most-enriched TFs at lncRNA promoters and an essential regulator of type 2 helper T-cell (Th2) cytokine production, is itself cis-regulated by an antisense lncRNA (GATA3-AS1), which is increased in patients with allergic rhinitis, a Th2-associated disease [64]. Here, GATA3 is linked to allergic rhinitis.