In breast cancer as well as in other cancers such as small cell lung, head and neck, renal cell, uterine cervical, and ovarian cancers, the expression of the THRB gene is frequently silenced either via chromosomal truncation and/or deletion in chromosome 3p where THRB lies, or via epigenetic changes in the promoter region of the THRB gene (e.g., hypermethylation; [10]. Here, THRB is linked to cancer.