In this regard, our current analysis of HNSCC-derived cells have identified multiple alterations underlying the decreased tumor suppressive effect of TGF-β in HNSCC, underscores the presence of TP53 mutations in a subset of HPV+ HNSCC cases, and revealed wide spread mutations and copy number variations in epigenetic modifiers, particularly of the Trithorax gene group. This evidence concerns the gene TP53 and neoplasm.