One of the factors that may have an association with the disease occurrence is HLA, which plays an important role in the body’s immune responses and development of autoimmune diseases especially class II HLA-DR and DQ.20 Guillain-Barré syndrome and its association with HLA typing are being studied in different countries worldwide.16,21 In this study, we found a significant association between HLA-DRB4*01:01, HLA-DRB1*07:01, and HLA-DRB1*03:01 in GBS patients with a significant increase of the HLA -DR2 and DR7 serotypes. The gene discussed is HLA-DRB1; the disease is autoimmune disease.