The HLAs corresponding to MHC class III encode components of the complement system.17 In GBS, there is macrophage activation with circulating activated T-lymphocytes evidenced by augmented expression of histocompatibility antigens (HLA-DR), suggesting that there is an association between GBS and HLA alleles.15,16 The HLA typing in GBS was investigated in several studies worldwide suggesting various associations.15,16,18 The aim of the current study is to investigate any association between GBS and HLA-DR. This evidence concerns the gene HLA-S and Guillain-Barre syndrome.