Conversely, we showed that inhibition of MMP-9 largely restored the levels of NKG2D-, NKp30- and Perforin-positive NK-92 cells, the secretion of TNF-α and IFN-γ and the cytotoxicity on NK cells against myelogenous leukemia K562 cells. The gene discussed is NCR3; the disease is myeloid leukemia.