In this study we applied a robust model selection framework composed of linear and non-linear statistical techniques for survival analysis, with the objective to test the predictive ability of existing risk scores for breast cancer in a population of BRCA1/2 carriers, and to improve over the current state-of-the-art, from the models based on early genotyping and familial assessment to the most recent SNP scoring, trying to combine both clinical/demographic information with high-resolution genetics. This evidence concerns the gene BRCA1 and breast cancer.