The median (95% CI) Kaplan-Meier estimate of survival time to breast cancer was 46.0 (44.9-48.1) years in the whole BRCA1 population, 53.7 (52.0-60.7) for menopause stratum, and 35.5 (32.9-38.3) for the ovulating population (p > 0.0001, log-rank test). The gene discussed is BRCA1; the disease is breast carcinoma.