IL6 and rheumatoid arthritis: Incubation with Ki16425 suppressed IL-6 production from LPA-stimulated RA FLSs as well as LA-01 (IL-6 concentrations: vehicle = 299.413 ± 28.084 pg/ml; Ki16425 = 116.785 ± 11.162 pg/ml (P < 0.05 vs vehicle); LA-01 = 145.715 ± 15.921 pg/ml (P < 0.05 vs vehicle)).