AREG and neoplasm: The aim of this study was therefore to examine and compare the effect of combined adjuvant chemotherapy with 5-FU/FA (folinic acid) versus the combination of 5-FU/FA and irinotecan in patients with locally advanced colon cancer in relation to tumor VEGF-C, VEGF-D, VEGFR-3, Hif-1 α, EREG, AREG and PTEN expression.