Here, we have shown another new mechanism for silencing of FHL1 expression in tumors: miR-410 not only specifically targets the 3′UTR of FHL1, but also promotes DNMT3A binding to the FHL1 promoter, which leads to its hypermethylation in cancer cells, suggesting that the regulation of FHL1 by miR-410 occurs by dual mechanisms. This evidence concerns the gene FHL1 and cancer.