Moreover, BRCA1 andBRCA2 mutations showed no evident influence on mitochondrialgenomes in breast cancer (Figure 5C), incontrast to their effects on nuclear genomes exhibiting an even distribution ofmutations across all trinucleotide contexts (Nik-Zainal et al., 2012a; Alexandrov etal., 2013). Here, BRCA1 is linked to breast cancer.