ZDHHC17 and Huntington disease: Moreover, palmitoylation of a zDHHC17 target protein, as well as palmitoylation of zDHHC17 itself, were found to be impaired in a mouse model of Huntington disease (44) and loss of zDHHC17 in mice produces a phenotype that recapitulates several features of Huntington disease (44, 45), indicating that a failure to maintain proper palmitoylation dynamics of zDHHC17 target proteins could be one of the pathological features in Huntington disease.