To determine whether increased amounts of nuclear FOXO3a in HD cells have functional consequences, we quantified the mRNA levels of FasL (Fas ligand), one of the target genes of FOXO3a (20), in Hdh7/7, Hdh7/109, and Hdh109/109 cells, as well as in untreated and 3-NP-treated primary cortical neurons by RT-qPCR. Here, FOXO3 is linked to Huntington disease.