Both smMLCK and nmMLCK phosphorylate myosin light chains to regulate cellular contraction and relaxation.5 smMLCK has been well studied in the pathogenesis of asthma as a key contributor to airway smooth muscle contractile function remodeling, characteristic of the asthmatic phenotype.6 In contrast, limited information is known about the role of the nmMLCK isoform in asthma pathobiology. The gene discussed is MYH14; the disease is asthma.