MYLK and asthma: Both smMLCK and nmMLCK phosphorylate myosin light chains to regulate cellular contraction and relaxation.5 smMLCK has been well studied in the pathogenesis of asthma as a key contributor to airway smooth muscle contractile function remodeling, characteristic of the asthmatic phenotype.6 In contrast, limited information is known about the role of the nmMLCK isoform in asthma pathobiology.