The most common of functioning lesions was PRL secreting pituitary adenomas (26.4 %), followed by GH-secreting pituitary adenomas (15.4 %), mixed GH/PRL secreting pituitary adenomas (2.2 %), and ACTH-secreting adenomas (5.8 %), followed by TSH secreting adenomas (0.6 %) (Table 2). This evidence concerns the gene POMC and adenoma.